The Brothers of Christian Instruction of the Province of St. Teresa of the Child Jesus, Uganda, drawing from their long standing mission and experience in the field of education, which goes as far back as 1926, and wishing to respond to the growing need for higher education grounded in the Catholic ethos, conceived the idea of founding a University in Uganda.
In 2004, the Brothers sought collaboration with Uganda Martyrs University (UMU) to realize this project. The Memorandum of Understanding (MoU), signed on August 15, 2004, allowed the Brothers of Christian Instruction to establish Kisubi Brothers Centre of Uganda Martyrs University (KBUMU). The University Centre was to provide university level courses at Kisubi campus, coordinated by UMU.
On March 27, 2009, the National Council for Higher Education (NCHE) granted KBUMU a College status and thus assumed the name of Kisubi Brothers University College (KBUC), becoming a constituent college of Uganda Martyrs University. On June 29, 2015 the NCHE granted KBUC a Provisional License to start operating as a full-fledged private university in Uganda under the name University of Kisubi, abbreviated as UniK. UniK was published in the Uganda gazette on November 20, 2015, thus completing the mandatory minimum requirement of three (3) years to become eligible for the Charter status as from November 20, 2018.